Pathogen-host adhesion between SARS-CoV-2 spike proteins from different variants and human ACE2 studied at single-molecule and single-cell levelsArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2-RBD acute respiratory syndrome addition adhere binding complex coronavirus Delta delta variant destabilized effective force spectroscopy highest host cell human ACE2 human Angiotensin-converting enzyme immunization Infection inhibit Interaction investigated molecular dynamics molecular mechanism monoclonal antibody Mutation mutations N501Y Neutralizing neutralizing antibody omicron pathogen-host adhesion. Probability produced RBD Receptor binding domain S477N SARS-CoV-2 SARS-CoV-2 spike protein single-cell single-cell level Spike protein tested the spike protein variant variants virus wild type [DOI] 10.1080/22221751.2022.2128887 PMC 바로가기
Comparable antigen-specific T cell responses in vaccinees with diverse humoral immune responses after the primary and booster BBIBP-CorV vaccinationArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] Anti-spike Antibody Response B cell B cell responses BBIBP-CorV booster booster vaccination CD4 CD8 comparable COVID-19 COVID-19 vaccines de novo demonstrated detectable dramatic increase Epidemic exhibited Features humoral immune response Humoral immunity humoral responses interferon-γ Neutralizing antibodies omicron remained S protein SARS-CoV-2 SARS-COV-2 infection serotype Severe case Shanghai significantly T cell T cell response T cell responses T cell responses. Th1 cytokine vaccination vaccinee vaccinees wild type [DOI] 10.1080/22221751.2022.2130101 PMC 바로가기
Neutralizing antibodies to SARS-CoV-2 variants of concern including Delta and Omicron in subjects receiving mRNA-1273, BNT162b2, and Ad26.COV2.S vaccinesArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Ad26.COV2.S Ad26.COV2.S vaccine antibody B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta BNT162b2 BNT162b2 vaccine booster center contributed Control COVID-19 Delta dose Effectiveness elicited faster FIVE Gamma immunization moderate mRNA-1273 mRNA-based vaccine Mutation Neutralizing Neutralizing antibodies neutralizing antibody omicron P.1 postvaccination prevention Protein pseudovirus receiving recipient recommendation robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant subject Support vaccination Vaccine vaccine efficacy variants of concern variants of concern (VOCs). VoC VOCs wild type [DOI] 10.1002/jmv.28032 PMC 바로가기
Evaluation of humoral immune responses induced by different SARS-CoV-2 spike trimers from wild-type and emerging variants with individual, sequential, and combinational delivered strategiesArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Antibody Response antibody response against autologous binding circulating coronavirus coronavirus disease COVID-19 Delta effective heterogenous homologous humoral immune response immunization immunogenicity indicated induce monovalent vaccine multivalent vaccine neutralizing antibody Neutralizing antibody response omicron produced regimen SARS-CoV-2 SARS-CoV-2 spike trimer significantly spike Spike protein spike trimer strain supported trimer Vaccination strategies Vaccination strategy Vaccine Vaccines variant Variant. variants viruses wild type wild-type [DOI] 10.1002/jmv.28081 PMC 바로가기
Fully Automated CRISPR-LAMP Platform for SARS-CoV-2 Delta and Omicron VariantsArticle Published on 2022-11-082022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] 95% confidence interval Accuracy amplification automated B.1.617.2 Combined CRISPR D614G Delta detect Detection limit diagnostic diagnostic systems IMPROVE limit mutant mutations omicron P681H P681R platform Point mutation RdRP reaction RNA SARS-CoV-2 SARS-CoV-2 strain sensitivity Sensitivity and specificity specificity spike stability T478K variants wild type [DOI] 10.1021/acs.analchem.2c03607 PMC 바로가기
Identification of hACE2-interacting sites in SARS-CoV-2 spike receptor binding domain for antiviral drugs screeningArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 변종, 치료제, [키워드] amino acid residue antiviral drug binding binding sites. Cefixime Ceftazidime cell entry Cephalosporin derivative clinical evaluation coronavirus 2 Critical derivative drug Drug screening example hACE2 human Angiotensin-converting enzyme identification Infection inhibited Interaction key amino acid live SARS-CoV-2 molecular docking Mutation peptide Pseudotyped virus pseudovirus RBD Receptor binding domain respiratory Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD Support targets tested the RBD the spike protein variants virus was determined wild type wildtype Wuhan [DOI] 10.1016/j.virusres.2022.198915 PMC 바로가기
Omicron BA.2.75 variant is efficiently neutralised following BA.1 and BA.5 breakthrough infection in vaccinated individuals, Israel, June to September 2022Article Published on 2022-11-012022-11-15 Journal: Eurosurveillance [Category] SARS, 변종, 진단, [키워드] Breakthrough infection dose evaluated HCW healthcare worker Infection infections neutralising neutralising antibody neutralising antibody titre omicron Omicron variants, neutralising antibodies SARS-CoV-2 SARS-CoV-2. uninfected vaccinated individual vaccinated individuals Vaccine variant variants wild type [DOI] 10.2807/1560-7917.ES.2022.27.44.2200785 PMC 바로가기
Prevalence of acute olfactory dysfunction differs between variants of SARS-CoV-2-results from chemosensitive testing in wild type, VOC alpha (B.1.1.7) and VOC delta (B.1617.2)Article Published on 2022-11-012022-11-16 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID19(2023년), SARS, 변종, [키워드] acute SARS-CoV-2 infection Alpha B.1.1.7 blinded COVID-19 dysfunction Hyposmia impairment Next-generation sequencing Olfaction olfactory olfactory dysfunction olfactory function Patient Prevalence Prospective Study quantitative real-time PCR SARS-CoV-2 significant difference Smell Smell. subsequent symptoms of COVID-19 variant variants virus virus variant VoC wild type [DOI] 10.1007/s00405-022-07431-6 PMC 바로가기
Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease VariantsArticle Published on 2022-10-302022-11-16 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Affect analysis analyzed biochemically bioinformatics catalytic caused changed characterization characterized cleavage Combination conserved coronavirus Coronaviruses Course COVID-19 pandemic domain drug design effort endoribonuclease endoribonuclease. EndoU evade Evolution facilitate Genome help Host immune response in vivo inactive increase in innate immune response middle monomeric Mutation N-terminal nonstructural proteins novel coronavirus SARS-CoV-2 Nsp15 oligomerization pandemic Patient prevalent Protein residue RNA SARS-CoV-2 SARS-CoV-2 sequence Sequencing Transcription triggering understanding variant viral genome Viral protein viral replication virus wild type [DOI] 10.1016/j.jmb.2022.167796 PMC 바로가기
Genomic Epidemiology and Serology Associated with a SARS-CoV-2 R.1 Variant Outbreak in New JerseyArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome antibody antibody resistance attack rate B.1.351 B.1.526 Care caused characteristic Clinical use collected Community Complete coronavirus COVID-19 Critical E484K mutation Evidence Examining exhibit exhibited hcp Health highlight individual infected individuals Infection Inpatient Lineage loss of activity monoclonal antibody Mutation N-terminal domain neutralization capacity Neutralizing antibody response neutralizing capacity New nosocomial NTD outbreak P.1 Patient plasma positive professional professionals proportion pseudovirus psychiatric facility Receptor binding domain reported reverse transcription robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera Spike protein Symptom symptomatic COVID-19 disease tested the SARS-CoV-2 the United State treat vaccinated individual vaccinated individuals vaccination Vaccine variant variants of concern variants of concern. VOCs wild type [DOI] 10.1128/mbio.02141-22 PMC 바로가기